Yohimbex (with ginseng root)

Yohimbine increases the amount of blood that flows into the penis and prevents blood from flowing out of the penis. It can cause an erection. Yohimbine is used to treat and diagnose some types of impotence.

Therapeutic actions:
Yohimbine Hydrochloride is a selective competitive alpha2-adrenergic receptor antagonist. The alpha2 receptor is responsible for sensing adrenaline and noradrenaline and telling the body to decrease its production as part of a negative feedback loop.
Yohimbine also antagonizes several serotonin receptor subtypes: 1A (inhibitory, behavioral control), 1B (inhibitory, vasoconstriction), 1D (inhibitory, vasoconstriction), and 2B (smooth muscle contraction). Since yohimbine is an antagonist, it will decrease the effects of these receptors, thus causing excitation, vasodilation, and smooth muscle relaxation. Yohimbine also increases dopamine and have some actions as an MAOI, although these mechanisms are unknown. Yohimbine and Yohimbine bark may also cause vasodilation through endothelin B receptor stimulation and nitric oxide (NO) release.

What is it used for?:
Yocon is used in the treatment of male impotence. The drug is thought to work by stimulating the release of norepinephrine, one of the body's natural chemical regulators. This results in increased blood flow to the penis.

Contraindications and cautions:
Yocon should not be used if you have kidney disease, or if you are sensitive to or have ever had an allergic reaction to yohimbine.

Side effects:
Serious: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); a very irregular or fast heartbeat; or confusion or unusual behavior. Other: dizziness; anxiety, irritability, or nervousness; tremor (shaking); headache; or skin flushing.

Interactions:
Yohimbine should not be used with preparation for depression, mania, or another psychiatric condition.