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Tobrex (tobramycin ophthalmic solution) 0.3% is a sterile topical ophthalmic antibiotic formulation prepared specifically for topical therapy of external ophthalmic infections. Tobramycin is a water-soluble aminoglycoside antibiotic active against a wide variety of gram-negative and gram-positive ophthalmic pathogens. Indications and usage: Tobrex is a topical antibiotic indicated in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany the use of Tobrex. Clinical studies have shown tobramycin to be safe and effective for use in children. Contraindications: Tobrex is contraindicated in patients with known hypersensitivity to any of its components. Warnings: For topical ophtalmic use only. Sensitivity to topically applied aminoglycosides may occur in some patients. If a sensitivity reaction to Tobrex (tobramycin ophthalmic solution) 0.3% occurs, discontinue use. Overdose: Clinically apparent signs and symptoms of an overdose of Tobrex (tobramycin ophthalmic solution) 0.3% (punctate keratitis, erythema, increased lacrimation, edema and lid itching) may be similar to adverse reaction effects seen in some patients.
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