Lamivudine + Stavudine 150 mg

This combination of Lamivudine and Stavudine is commonly used in the management of HIV infection. Both Lamivudine and Stavudine belong to the neucleoside analogue class of antiretroviral drugs.

Uses
Both drugs act by inhibiting the reverse transcriptase of HIV, and by terminating the growth of the DNA chain. Stavudine in combination with lamivudine has been shown to have synergistic antiretroviral activity.

Each Combination Tablet contains half of the commonly prescribed daily doses of both stavudine and lamivudine. With the availibility of this combination tablet patients maybe better able to adhere to complex drug treatmen regimens, thereby enhancing complaince.

Recommended Dose:
Adults : For patients weighing <60 Kgs Take Lamivudine 150mg + Stavudine 30mg, 1 Tablet, Twice daily.
Adults : For patients weighing >=60 Kgs Take Lamivudine 150mg + Stavudine 40mg, 1 Tablet, Twice daily.

Please consult your health care professional before taking this combination and take exactly as prescribed. As this is a fixed dose combination, this medication should not be prescribed for patients requiring dosage adjustment, such as those with reduced renal function, those with low body weight(<50 Kgs or 110lb), or those experiencing dose limiting adverse events.

Side Effects
Lactic Acidosis and severe Hepatomegaly with steatosis, including fatal cases, have been reported with the use of neucleoside analogues alone or in combination including lamivudine and stavudine.
Consult your health care professional for more information.

Interaction
This medication is contraindicated in patients with clinically significant hypersensitivity to any of the components contained in the formulation.

Overdose
Lamivudine : There is no known antidote for Lamivudine. It is not known whether lamivudine can be removed by peritoneal dyalisis or haemodialysis.

Stavudine : Stavudine can be removed by haemodialysis. Experience with adults treated with 12 to 24 times the recommended daily dosage revealed no acute toxicity. Complications of chronic overosage include peripheral neuropathy and hepatic toxicity.